# E1A The Extent of Population Exposure to Assess Clinical Safety: For Drugs Intended for Long-term Treatment of Non-Life-Threatening Conditions - FDA Guidance Document Source: https://www.globalkeysolutions.net/guidances/guidance-document/e1a-the-extent-of-population-exposure-to-assess-clinical-safety-for-drugs-intended-for-long-term-treatment-of-non-life-threatening-conditions/71a56556-e3ab-4bf3-8fd7-bbf16d42b30a > FDA guidance document: E1A The Extent of Population Exposure to Assess Clinical Safety: For Drugs Intended for Long-term Treatment of Non-Life-Threatening Conditions. Issue date: March 01, 1995. Get complete insights and analysis. --- ## Details - Title: E1A The Extent of Population Exposure to Assess Clinical Safety: For Drugs Intended for Long-term Treatment of Non-Life-Threatening Conditions - Communication Type: Guidance Document - Product Type: drugs - Office Name: Center for Drug Evaluation and Research - Office URL: /offices/center-for-drug-evaluation-and-research/cd980d74-1cbf-4226-ba9a-9045324c236c - Issue Date: 1995-03-01 - Last Changed: 2020-04-29 - Docket Number: FDA-1994-D-0267 ## Related Documents - [S3B Pharmacokinetics: Guidance for Repeated Dose Tissue Distribution Studies](https://www.globalkeysolutions.net/guidances/guidance-document/s3b-pharmacokinetics-guidance-for-repeated-dose-tissue-distribution-studies/05507ee5-4516-40d8-9c89-68fe4835e9fd) - [M5International Conference on Harmonisation; Draft Guidance on M5 Data Elements and Standards for Drug Dictionaries](https://www.globalkeysolutions.net/guidances/guidance-document/m5international-conference-on-harmonisation-draft-guidance-on-m5-data-elements-and-standards-for-drug-dictionaries/d4c223eb-7ce8-43b0-9cf7-93a7d505c695) - [E12A Principles for Clinical Evaluation of New Antihypertensive Drugs](https://www.globalkeysolutions.net/guidances/guidance-document/e12a-principles-for-clinical-evaluation-of-new-antihypertensive-drugs/a715b1f0-1946-46b1-8a7f-cd01a428224d)